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Meanwhile in my backyard the west siders wanna cut the line.
the comments on this article is just people wanting to get mad at something. We have people waiting hours to get doses of the vaccine that would otherwise go bad if they weren’t there to use them. That’s objectively great, good for them.
As long as they get seniors and health care workers out of the line first, I really don't have a problem with vaccine chasers. If I have a shot that is going to waste and no one "eligible" to give it to, I'm going to find someone to poke.
Super duper preliminary numbers, but good news out of Israel, who has given the first dose of the vaccine to more of it's people than any other country:
With this in store for many countries, Israel is the place to watch for the first evidence about how mass vaccination may change things, for it has vaccinated its citizens faster than anywhere else. By January 19th, a month after the campaign had begun, Israel had given 26% of its 9m people at least one dose. As has happened elsewhere, it started with older people. And for them, some results are now emerging.
In a recent analysis, Ran Balicer of the Clalit Research Institute in Tel Aviv and his colleagues compared, day by day, a group of 200,000 over-60s who had been vaccinated with an otherwise-similar group of unvaccinated individuals. They tracked differences in infection rates between the groups by comparing test results for people in them who were tested for covid after reporting pertinent symptoms or close contact with someone who had previously tested positive.
For the study’s first 12 days, positive test rates remained identical between groups. On the 13th, the vaccinated group’s rate fell slightly. Then, on day 14, it dropped by a third. There has been some disappointment that this drop was not greater, but the vaccine in question, the Pfizer-BioNTech offering, is intended to be given in two doses, so the picture will not be clear until the second doses have been administered, and results from younger people have been included, too.
The early effect on hospital admissions of Israel’s mass vaccination campaign has been trickier to measure, because of two confounding variables: the country’s national lockdown, which tends to reduce the rate regardless of the effect of vaccines, and the spread of b.1.1.7, a variant of the virus first found in Britain, which is a lot more contagious and so tends to push the rate up. This combination of factors is, though, also being experienced in many European countries, and in parts of the United States, so what happens in Israeli hospitals now is a harbinger of what those other places can expect in coming weeks and months.
A sign that vaccination is starting to give Israeli hospitals some breathing space emerged a fortnight after January 2nd, the day when the proportion of those over 60 who had been vaccinated reached 40%. The number critically ill with covid-19 in that age group grew by about 30% in the week before January 2nd, and also in the following week—but by just 7% in the week after that (see chart 2). By contrast, among those aged between 40 and 55 (who were vaccinated at a much lower rate at the time) the weekly change in the number of critically ill remained constant, with a 20-30% increase in each of those three weeks.
Taking such early results into a model of the epidemic’s trajectory, Eran Segal of the Weizmann Institute and his colleagues reckon that covid-19 deaths in Israel could start tapering off early in March, even if the lockdown ends, as planned, in the last week of January. Their prognosis assumes that the pace of vaccination holds up, and that 80% of adults get their second dose by the end of February. (The other 20% are people who cannot be vaccinated for reasons such as allergies, or who refuse to be vaccinated.)
Meanwhile in my backyard the west siders wanna cut the line.
the comments on this article is just people wanting to get mad at something. We have people waiting hours to get doses of the vaccine that would otherwise go bad if they weren’t there to use them. That’s objectively great, good for them.
As we say here: Fuck the westsiders. Itll be the only time those people would ever go into a lower income part of the city. If the clinics know theyll have expiring doses and leftover you set it up so that the eligible demographics receive them and not have this shit happen right now. Lets gentrify receiving the vaccine now, thats what theyre good at anyway.
As long as they get seniors and health care workers out of the line first, I really don't have a problem with vaccine chasers. If I have a shot that is going to waste and no one "eligible" to give it to, I'm going to find someone to poke.
See above. And these are the same people that are acting like their lives havent changed at all this entire time and now wanna find another shortcut for themselves. This city is class divided so much that there should be outrage about it.
Post by problem dog on Jan 24, 2021 11:57:23 GMT -5
Organization has been terrible. I think it's depressing and gross that wealthy, healthy people seem to have an easier time finding leftover doses, but vaccinating more people is still a net positive. Blame the people who dropped the ball on distributing the vaccine in an effective, equitable way, not the people trying to get vaccinated.
Post by Jeremy Jamm on Jan 24, 2021 19:45:02 GMT -5
Question: If the mRNA vaccine can be changed/alerted very quickly, shouldn't they just go ahead and do that to protect again the new strains for future production? Would they still need to run trials for it?
the comments on this article is just people wanting to get mad at something. We have people waiting hours to get doses of the vaccine that would otherwise go bad if they weren’t there to use them. That’s objectively great, good for them.
As we say here: Fuck the westsiders. Itll be the only time those people would ever go into a lower income part of the city. If the clinics know theyll have expiring doses and leftover you set it up so that the eligible demographics receive them and not have this shit happen right now. Lets gentrify receiving the vaccine now, thats what theyre good at anyway.
As long as they get seniors and health care workers out of the line first, I really don't have a problem with vaccine chasers. If I have a shot that is going to waste and no one "eligible" to give it to, I'm going to find someone to poke.
See above. And these are the same people that are acting like their lives havent changed at all this entire time and now wanna find another shortcut for themselves. This city is class divided so much that there should be outrage about it.
How do you propose they do this? The leftover doses are a result of people not showing up to their appointments. They are already limiting appointments to those being prioritized. The three options seem to be overbook appointments and potentially not have enough doses for everyone with appointments, let doses go to waste because the people waiting aren't in the prioritized groups, or give the excess doses that are going to expire caused by no shows to people waiting outside. Definitely seems like they are doing the right thing.
Last Edit: Jan 24, 2021 20:13:36 GMT -5 by r - Back to Top
Question: If the mRNA vaccine can be changed/alerted very quickly, shouldn't they just go ahead and do that to protect again the new strains for future production? Would they still need to run trials for it?
I asked this question last week in /r/COVID19's weekly question thread, and someone pointed me to this article, which says that Oxford is already working on tweaking their vaccine to accommodate for the new variants. While there's been no public statement about it, I'd bet solid money that Pfizer and Moderna are doing the same for the major variants of concern.
In terms of trials...as of right now, yes, but the FDA makes a special exception for the flu vaccine, which needs to be updated every year - if I recall correctly, they have to do a very brief, small trial to indicate immunogenicity when they spin up a new version for that year's strain, and then it's off to the races. I'd be legit surprised if something similar were not embraced for these vaccines given the urgency of the situation.
My big remaining question is whether what we'd be looking at would be individual new versions of the vaccine targeted at certain variants, or a multivalent vaccine that generates immune response against multiple variants. Those do exist for other diseases, but I have no idea if the mRNA or adenovirus platforms can do that, or not.
Do you want to dance while also thinking about all the ways you've failed as a human?
UPCOMING SHOWS 4/4 - Young Fathers @ Brooklyn Steel 5/14 - Neil Young & Crazy Horse @ Forest Hills Stadium 8/17 - King Gizzard & the Lizard Wizard @ Forest Hills Stadium 9/4 - Pearl Jam @ MSG 9/7 - Pearl Jam @ Wells Fargo Center 9/13 - The War on Drugs/The National @ Forest Hills Stadium
From the limited research I did to explain to someone why there is no cold vaccine, the answer is that there are a number of pathogens that cause "the common cold". To innoculate against the cold, a vaccine would have to have like 100+ strains in it.
Question: If the mRNA vaccine can be changed/alerted very quickly, shouldn't they just go ahead and do that to protect again the new strains for future production? Would they still need to run trials for it?
Moderna has stated that they would not require new trials to change the variant of the vaccine. They are however waiting to determine if any of the new variants are resistant to the vaccine before they make a change.
edit-one good thing is the flu vaccine has given us a lot of practice at this.
Question: If the mRNA vaccine can be changed/alerted very quickly, shouldn't they just go ahead and do that to protect again the new strains for future production? Would they still need to run trials for it?
Moderna has stated that they would not require new trials to change the variant of the vaccine. They are however waiting to determine if any of the new variants are resistant to the vaccine before they make a change.
edit-one good thing is the flu vaccine has given us a lot of practice at this.
Hot off the presses, Moderna just put out a release that basically says the following things:
1) No change in neutralization vs. the British variant.
2) There is a six-fold reduction in neutralizing titers vs. the South African variant, but "Despite this reduction, neutralizing titer levels with B.1.351 remain above levels that are expected to be protective."
3) They are currently working on testing two solutions to the problem of these emerging variants: a) An additional, third booster shot of the original formula. b) "An emerging variant booster candidate (mRNA-1273.351) against the B.1.351 variant first identified in the Republic of South Africa."
They're entering Phase 1 trials now on the latter.
Do you want to dance while also thinking about all the ways you've failed as a human?
UPCOMING SHOWS 4/4 - Young Fathers @ Brooklyn Steel 5/14 - Neil Young & Crazy Horse @ Forest Hills Stadium 8/17 - King Gizzard & the Lizard Wizard @ Forest Hills Stadium 9/4 - Pearl Jam @ MSG 9/7 - Pearl Jam @ Wells Fargo Center 9/13 - The War on Drugs/The National @ Forest Hills Stadium
Do you want to dance while also thinking about all the ways you've failed as a human?
UPCOMING SHOWS 4/4 - Young Fathers @ Brooklyn Steel 5/14 - Neil Young & Crazy Horse @ Forest Hills Stadium 8/17 - King Gizzard & the Lizard Wizard @ Forest Hills Stadium 9/4 - Pearl Jam @ MSG 9/7 - Pearl Jam @ Wells Fargo Center 9/13 - The War on Drugs/The National @ Forest Hills Stadium
Post by ilovethisgame on Jan 25, 2021 16:14:16 GMT -5
Just got my second dose of the Pfizer vaccine. I'll let you know what color my new tail is when it appears. In all seriousness though, I took the next two days off of work because I've heard the second dose can be a doozy.
Mrs Gazer got the second shot of the Pfizer vaccine yesterday and has so far only felt a little tired today, and sore in her arm where she got the shot. No major side effects as of now.
Beijing officials who had hoped the vaccines would burnish China’s global reputation are now on the defensive. State media has started a misinformation campaign against the American vaccines, questioning the safety of the Pfizer and Moderna shots and promoting the Chinese vaccines as a better alternative. It has also distributed online videos that have been shared by the anti-vaccine movement in the United States.
Probably approved and available to ship by March. 90% effective rate with one shot. Only refrigeration needed. They are wrapping up the phase three trial at Vandy now. Also a two shot regimen is in trials. 100 million doses by end of April. (If all goes as planned)
this is the ticket i think. get this out and into arms, combined with pfizer and moderna, and pandemic over.
couple other covid news tidbits:
-yesterday moderna said preliminary results show their two-dose regimen is effective against the UK and South Africa strains (but as previously discussed they are coming up with a booster shot anyway)
-yesterday the president said they are now aiming for 1.5 million doses a day instead of 1 million. he thinks by this spring anybody who wants a vaccine will be able to get one, and America will be "heading toward herd immunity" by this summer. i know the president is a politician but typically politicians try to undersell and overdeliver so his confidence gives me confidence.
reminds me of when i was in college and bought the first iPod. i was sitting there holding this thing in my hands knowing it would change everything. but unfortunately at the time all my wealth was wrapped up in an iPod, an eighth, and a twelve pack of busch heavy.