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Post by jorgeandthekraken on Dec 14, 2021 11:46:55 GMT -5
Some good news at a time when there's a lot of Omicron-related bad news:Pfizer's antiviral pill, Paxlovid, finished its first trial, and the 89% reduction in hospitalizations they reported at their interim analysis held up. This was among unvaccinated patients considered high-risk. Some highlights:
- 5 of 697 patients in the treatment arm were hospitalized, compared with 44 of 682 in the placebo arm.
- In the interim analysis, it initially seemed like effectiveness dropped when the treatment was taken within five days of symptom onset vs. within 3 days. That no longer appears to be the case, as Pfizer is reporting 88% reduction in hospitalization when taken within five days of symptom onset.
- Zero deaths occurred in the treatment arm, as compared with 12 in the placebo arm.
They also are doing a smaller trial with patients who were unvaccinated and not high-risk + patients who were vaccinated but considered higher-risk, and published interim analysis thereof.. The numbers there aren't as exciting, but it's primarily because a) the total pool of participants wasn't huge, yet, and b) the absolute numbers of poor outcomes were so low that it's hard to draw any real conclusions from it so far. Still, it's promising, if incomplete:
- Treatment arm: 2 of 333 hospitalized, no deaths
- Placebo arm: 8 of 329 hospitalized, no deaths
That trial is ongoing.
So, now, the FDA just needs to get the fuck off its fucking ass and give this thing an EUA, already. Pfizer says it can manufacture something like 200,000 courses of treatment this year, and a shit-ton more next year. Since it's a protease inhibitor and not dependent on the spike protein configuration, it's still going to work vs. Omicron. This could really make a dent.
Do you want to dance while also thinking about all the ways you've failed as a human?
UPCOMING SHOWS 6/8 and maybe 6/9 - Governors Ball 8/17 - King Gizzard & the Lizard Wizard @ Forest Hills 9/4 - Pearl Jam @ MSG 9/7 - Pearl Jam @ Wells Fargo Center 9/11 - St. Vincent @ Brooklyn Paramount 9/19 - Stars @ Music Hall of Williamsburg 9/20 - Khruangbin @ Forest Hills
Imagine being so provax that you join a vax study and they give you the placebo.
I'm...not sure what your point is, here. People volunteer for these studies knowing they could end up in the placebo arm. And there's no guarantee the treatment arm is going to do better - that's kind of the whole point of the trial.
Do you want to dance while also thinking about all the ways you've failed as a human?
UPCOMING SHOWS 6/8 and maybe 6/9 - Governors Ball 8/17 - King Gizzard & the Lizard Wizard @ Forest Hills 9/4 - Pearl Jam @ MSG 9/7 - Pearl Jam @ Wells Fargo Center 9/11 - St. Vincent @ Brooklyn Paramount 9/19 - Stars @ Music Hall of Williamsburg 9/20 - Khruangbin @ Forest Hills
Considering you've found the need to respond to my threads as if you are threatened by me I offer you some peace my confused counterpart. May you find peace in your restless soul.
I mean...yeah. It does. I'm not disputing what you said. It sucks. I was reacting more to the idea put out by abefroman1 that it's some crazy irony for someone to volunteer for a vaccine trial - or any RCT, really - and then get the placebo.
Also, these aren't challenge trials - the enrollees who died of COVID during the course of the Paxlovid trial would have died whether they were in the trial, or not. They already had COVID. They were already unvaccinated. They were already high-risk for severe disease and death. Their deaths were tragic, as every death from this virus is, but I guess I don't feel they were somehow made more tragic because they were in this trial, you know?
I don't know. I don't think anybody would dispute that it would be better if there were a way to do clinical trials that didn't involve human participation and control groups. But this is what we have. If these people were going to die of COVID, at least, as Druid said, their deaths'll save so many lives.
Do you want to dance while also thinking about all the ways you've failed as a human?
UPCOMING SHOWS 6/8 and maybe 6/9 - Governors Ball 8/17 - King Gizzard & the Lizard Wizard @ Forest Hills 9/4 - Pearl Jam @ MSG 9/7 - Pearl Jam @ Wells Fargo Center 9/11 - St. Vincent @ Brooklyn Paramount 9/19 - Stars @ Music Hall of Williamsburg 9/20 - Khruangbin @ Forest Hills
Post by jorgeandthekraken on Dec 14, 2021 18:22:53 GMT -5
Also, I'm genuinely sorry if I'm coming across as polemic. I'll admit, I see the word "provax," and it instantly strikes me as not the kind of thing someone pro-vaccine would say. Anti-vaccine sentiment, at this stage, brings out a lot of anger that I sometimes have difficulty managing.
I'm definitely not trying to attack anyone who was just expressing sympathy for the dead, and if that's how I'm coming across, that's totally my bad.
Do you want to dance while also thinking about all the ways you've failed as a human?
UPCOMING SHOWS 6/8 and maybe 6/9 - Governors Ball 8/17 - King Gizzard & the Lizard Wizard @ Forest Hills 9/4 - Pearl Jam @ MSG 9/7 - Pearl Jam @ Wells Fargo Center 9/11 - St. Vincent @ Brooklyn Paramount 9/19 - Stars @ Music Hall of Williamsburg 9/20 - Khruangbin @ Forest Hills
Yall think we hit a record high of daily new cases after the holidays? Right now I think we're going to. Numbers are already pretty high, Omicron is here, and our guard is down. Everybody's about to be flying all over the place and bringing it to their communities.
I don't know if Omicron is responsible for what's going on in the NFL and NBA right now, but it's extremely unnerving the way cases are exploding in those leagues. Numbers are up in the general population too, supposedly a lot of it driven by children.
Post by crazykittensmile on Dec 17, 2021 14:27:54 GMT -5
Fucking hell, they moved the 2-4 year old vaccine goalpost AGAIN. Isn't some protection better than NONE? Jesus I am so sick of not being able to protect my kid. At this rate he'll be 5 before he can even get fucking vaccinated (8 months away!)
When tested in children ages 2 to 4, the two-shot regimen failed to meet a laboratory standard for immune response set in an older age group, according to a statement. The vaccine partners said they amended their clinical trial protocol following a request by an external, independent data-monitoring committee. No safety concerns were identified among the young children.
If three doses prove successful, Pfizer and BioNTech will approach the U.S. Food and Drug Administration for an emergency-use authorization for the regimen in that age group in the first half of 2022.
Yikes. Imagine you got outran so badly the CDC saying don't even bother
to be fair the CDC has been next level bad for a while now, so who knows what to think of this. I remember when people on here were talking about how Biden was being like Trump when he was pushing for everyone to get the booster 4 months ago against the FDA and CDC's suggestions
Yikes. Imagine you got outran so badly the CDC saying don't even bother
to be fair the CDC has been next level bad for a while now, so who knows what to think of this. I remember when people on here were talking about how Biden was being like Trump when he was pushing for everyone to get the booster 4 months ago against the FDA and CDC's suggestions
To be even more fair, there was a not-at-all-insubstantial debate going on at the time in the scientific community as to whether boosters were either necessary at all (if the goal was to prevent hospitalization and death, which seemed to hold up vs. Delta and even after NAbs waned), or necessary enough that pushing for them vs. wider vaccine equity wasn't a mistake.
Obviously, Omicron has changed all that. As for J&J, it's not the case that their vaccine sucks. This variant changed everything for everyone. We're lucky as hell that a) it's not immune escape entirely, and b)booster doses of the mRNA vaccines held up as well as they do. We're racing against an opponent that's faster than the scientific process that typically produces ways to fight back. It sucks. It's a bad hand for everyone.
Do you want to dance while also thinking about all the ways you've failed as a human?
UPCOMING SHOWS 6/8 and maybe 6/9 - Governors Ball 8/17 - King Gizzard & the Lizard Wizard @ Forest Hills 9/4 - Pearl Jam @ MSG 9/7 - Pearl Jam @ Wells Fargo Center 9/11 - St. Vincent @ Brooklyn Paramount 9/19 - Stars @ Music Hall of Williamsburg 9/20 - Khruangbin @ Forest Hills
Do you want to dance while also thinking about all the ways you've failed as a human?
UPCOMING SHOWS 6/8 and maybe 6/9 - Governors Ball 8/17 - King Gizzard & the Lizard Wizard @ Forest Hills 9/4 - Pearl Jam @ MSG 9/7 - Pearl Jam @ Wells Fargo Center 9/11 - St. Vincent @ Brooklyn Paramount 9/19 - Stars @ Music Hall of Williamsburg 9/20 - Khruangbin @ Forest Hills
Post by Hector Salamanca on Dec 17, 2021 17:22:08 GMT -5
Hoping someone in here might have an answer - should I push back getting boosted (scheduled for Tuesday) if I tested positive this past Saturday the 11th with first having felt symptoms Thursday the 9th?
(if anyone is wondering btw I am fine, few days of a bad cold and pretty much normal now which sure seems like Omnicron to me but idk)
Hoping someone in here might have an answer - should I push back getting boosted (scheduled for Tuesday) if I tested positive this past Saturday the 11th with first having felt symptoms Thursday the 9th?
(if anyone is wondering btw I am fine, few days of a bad cold and pretty much normal now which sure seems like Omnicron to me but I don't know)
Can you get in touch with your primary care physician between now and then? They'd probably have the best answer.
Do you want to dance while also thinking about all the ways you've failed as a human?
UPCOMING SHOWS 6/8 and maybe 6/9 - Governors Ball 8/17 - King Gizzard & the Lizard Wizard @ Forest Hills 9/4 - Pearl Jam @ MSG 9/7 - Pearl Jam @ Wells Fargo Center 9/11 - St. Vincent @ Brooklyn Paramount 9/19 - Stars @ Music Hall of Williamsburg 9/20 - Khruangbin @ Forest Hills
Hoping someone in here might have an answer - should I push back getting boosted (scheduled for Tuesday) if I tested positive this past Saturday the 11th with first having felt symptoms Thursday the 9th?
(if anyone is wondering btw I am fine, few days of a bad cold and pretty much normal now which sure seems like Omnicron to me but I don't know)
Can you get in touch with your primary care physician between now and then? They'd probably have the best answer.
Glad to hear you're OK, though.
No I only want crowdsourced answers from music fest forums!! (Yes, that's definitely the right move)
Can you get in touch with your primary care physician between now and then? They'd probably have the best answer.
Glad to hear you're OK, though.
No I only want crowdsourced answers from music fest forums!! (Yes, that's definitely the right move)
I definitely didn't mean it in a dickhead sort of way. Just, y'know, not sure anyone here could give you a real answer.
What I've read from reputable sources varies. At baseline, it's that you should wait until your symptoms are gone. Other sources say wait until symptoms are gone and you're 10 days past when they started, whichever comes second. Another one I saw said wait four weeks.
Do you want to dance while also thinking about all the ways you've failed as a human?
UPCOMING SHOWS 6/8 and maybe 6/9 - Governors Ball 8/17 - King Gizzard & the Lizard Wizard @ Forest Hills 9/4 - Pearl Jam @ MSG 9/7 - Pearl Jam @ Wells Fargo Center 9/11 - St. Vincent @ Brooklyn Paramount 9/19 - Stars @ Music Hall of Williamsburg 9/20 - Khruangbin @ Forest Hills
Hoping someone in here might have an answer - should I push back getting boosted (scheduled for Tuesday) if I tested positive this past Saturday the 11th with first having felt symptoms Thursday the 9th?
(if anyone is wondering btw I am fine, few days of a bad cold and pretty much normal now which sure seems like Omnicron to me but idk)
You can get a booster 10 days after your COVID symptoms started.
No I only want crowdsourced answers from music fest forums!! (Yes, that's definitely the right move)
I definitely didn't mean it in a dickhead sort of way. Just, y'know, not sure anyone here could give you a real answer.
What I've read from reputable sources varies. At baseline, it's that you should wait until your symptoms are gone. Other sources say wait until symptoms are gone and you're 10 days past when they started, whichever comes second. Another one I saw said wait four weeks.
So...yeah. Doctor.
lol you're all good man just screwing around - appreciate the input from you and Druid too
Post by Jeremy Jamm on Dec 17, 2021 18:35:45 GMT -5
Seems to be a lot of reports that boosted folks are at about 50-80% against symptomatic infection of omicron. Granted, even best case scenario in a few weeks that's not going to be very much of the population.
I guess I shouldve just taken the second Moderna dose back in Sept if this is where it was all gonna end up. Booked an appointment for tuesday to get my now 3rd shot. Hoping this isnt the one that hits me like a ton of bricks. Ill take just another sore arm for 3 days.
I guess I shouldve just taken the second Moderna dose back in Sept if this is where it was all gonna end up. Booked an appointment for tuesday to get my now 3rd shot. Hoping this isnt the one that hits me like a ton of bricks. Ill take just another sore arm for 3 days.
Word. I got Moderna x3 yesterday when I was in Florida. That’s what I got in about a sliver dollar size space on the upper arm. Arm hurt the worst after the first shot which my shoulder hurt for a week, and it was hard to sleep on that side. One of my kids was with me and he got sick as shit with nausea/hurling, headaches chills and the Hershey squirts. We thought maybe he picked up a bug in addition to shot effects, but there’s no way to know.